Dr. Neo Cortex

Dr. Neo Cortex is the main antagonist of the Crash Bandicoot video game series. He is an evil genius who uses his intellect in his plans of world domination. Although his intentions are to destroy Crash Bandicoot, he and Crash had worked together, in the 2004 Crash Bandicoot video game, Crash Twinsanity, appearing as the deuteragonist, forcibly working with Crash to stop the game's antagonists, the Evil Twins, he and Crash also worked together in Skylanders: Imaginators teaching Imaginator Skylanders how to use certain weapons and is a sensei along with Crash.

For his English voice actors, he has been portrayed by Brendan O'Brien, Clancy Brown, and Lex Lang as a adult, and Debi Derryberry and Corey Burton in a younger form. For his Japanese voice actors, he has been portrayed by Shōzō Iizuka as a adult and Yōsuke Akimoto and Noriko Suzuki when younger.